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EPAM’s Drug Information Database Increases Awareness of Adverse Effects

The client is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, improve care, and sometimes make groundbreaking discoveries that advance the boundaries of knowledge and human process

Each year, the company publishes more than 250,000 articles in over 2,200 journals.

The client recognized a need for a database that compiles diverse information on the adverse effects of drugs marketed in the U.S. and Europe. EPAM helped create a drug information database to meet the client's specification on-time and on-budget.

Key Challenges

  • Compiling diverse information on the adverse effects of drugs marketed in the U.S. and Europe
  • Collecting data from a wide variety of information sources (XML files, databases, images, PDF files, chemical structure and reaction files, graphs, text documents, spreadsheets, etc.)
  • Making data available to a wide variety of users, including chemists, biologists, regulators, and business managers

Solution Highlights

  • From the setup and requirements phase to the R&D phase to the application's initial launch, EPAM’s cross-functional teams worked with the client to complete the following development initiatives:Extracted detailed toxicology and adverse effects information from diverse sources into database fields
  • Semi-manually curated, integrated, and pooled efficacy, toxicity, adverse effect, drug-drug interaction, mode of action and PK information from FDA and EMEA approval packages and scientific publications for over 4,500 drugs from over 45,000 image and text files totaling 2,500,000 pages
  • Developed numerous methodologies, tools, and templates for data curation

The Results

  • Comprehensive yet easy-to-use web user interface with the ability to access:
    • Various points of entry to find needed information
    • Different views of the data (pre-clinical, clinical, and post-market)
    • Different levels of detail (summary tables, experimental detail, full text where available)
  • Ability to quickly determine toxicology and adverse effects of thousands of drugs marketed in the U.S. and Europe
  • Option to filter searches by drug name, adverse effect/toxicity, species, dose, dose type, route, source document, and year


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